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Telavancin profile in patients with complicated skin and skin structure infections and varying degrees of renal impairment

A study of 513 patients with complicated skin structure and skin structure infections (cSSSI) due to Gram-positive bacteria was conducted to simulate plasma concentration time profiles in patients with varying degrees of renal function. The percentage of patients with an area under the curve/minimum inhibitory concentration (AUC/MIC) ratio of > 219 was also calculated. The simulated dosing regimen was based on telavancin 10 mg/kg/24 h for patients with creatinine clearance (CrCl) > 50 mL/min; 7.5 mg/kg/24 h for CrCl 30-50 mL/min and 10 mg/kg/48 h for CrCl < 30 mL/min. The percentage of patients with AUC/MIC ratios 219 or greater was 100% in patients across the CrCl ranges described above if ...